A mesenchymal stem cell potency assay.
Ontology highlight
ABSTRACT:
SUBMITTER: Jiao J
PROVIDER: S-EPMC3759509 | biostudies-other | 2011
REPOSITORIES: biostudies-other
Publications
A mesenchymal stem cell potency assay.
Jiao Joy J Milwid Jack M JM Yarmush Martin L ML Parekkadan Biju B
Methods in molecular biology (Clifton, N.J.) 20110101
Mesenchymal stem cells (MSCs) are capable of modulating the immune system and have been used to successfully treat a variety of inflammatory diseases in preclinical studies. Recent evidence has implicated paracrine signaling as the predominant mechanism of MSC therapeutic activity. We have shown in models of inflammatory organ failure that the factors secreted by MSCs are capable of enhancing survival, downregulating inflammation, and promoting endogenous repair programs that lead to the reversa ...[more]
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