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Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population.

ABSTRACT: Genome-wide association studies (GWAS) have identified dozens of common genetic variants associated with risk of colorectal cancer (CRC). However, the majority of CRC heritability remains unclear. In order to discover low-frequency, high-risk CRC susceptibility variants in Swedish population, we genotyped 1 515 CRC patients enriched for familial cases, and 12 108 controls. Case/control association analysis suggested eight novel variants associated with CRC risk (OR 2.0-17.6, p-value < 2.0E-07), comprised of seven coding variants in genes RAB11FIP5, POTEA, COL27A1, MUC5B, PSMA8, MYH7B, and PABPC1L as well as one variant downstream of NEU1 gene. We also confirmed 27 out of 30 risk variants previously reported from GWAS in CRC with a mixed European population background. This study identified rare, coding sequence variants associated with CRC risk through analysis in a relatively homogeneous population. The segregation data suggest a complex mode of inheritance in seemingly dominant pedigrees.

SUBMITTER: Jiao X 

PROVIDER: S-EPMC5856271 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Recurrent, low-frequency coding variants contributing to colorectal cancer in the Swedish population.

Jiao Xiang X   Liu Wen W   Mahdessian Hovsep H   Bryant Patrick P   Ringdahl Jenny J   Timofeeva Maria M   Farrington Susan M SM   Dunlop Malcolm M   Lindblom Annika A  

PloS one 20180316 3

Genome-wide association studies (GWAS) have identified dozens of common genetic variants associated with risk of colorectal cancer (CRC). However, the majority of CRC heritability remains unclear. In order to discover low-frequency, high-risk CRC susceptibility variants in Swedish population, we genotyped 1 515 CRC patients enriched for familial cases, and 12 108 controls. Case/control association analysis suggested eight novel variants associated with CRC risk (OR 2.0-17.6, p-value < 2.0E-07),  ...[more]

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