Impact of low-frequency coding variants on human facial shape.
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ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC7804299 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Impact of low-frequency coding variants on human facial shape.
Liu Dongjing D Alhazmi Nora N Matthews Harold H Lee Myoung Keun MK Li Jiarui J Hecht Jacqueline T JT Wehby George L GL Moreno Lina M LM Heike Carrie L CL Roosenboom Jasmien J Feingold Eleanor E Marazita Mary L ML Claes Peter P Liao Eric C EC Weinberg Seth M SM Shaffer John R JR
Scientific reports 20210112 1
The contribution of low-frequency variants to the genetic architecture of normal-range facial traits is unknown. We studied the influence of low-frequency coding variants (MAF < 1%) in 8091 genes on multi-dimensional facial shape phenotypes in a European cohort of 2329 healthy individuals. Using three-dimensional images, we partitioned the full face into 31 hierarchically arranged segments to model facial morphology at multiple levels, and generated multi-dimensional phenotypes representing the ...[more]
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