Ontology highlight
ABSTRACT:
SUBMITTER: Dellibovi-Ragheb TA
PROVIDER: S-EPMC5856565 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Dellibovi-Ragheb Teegan A TA Jhun Hugo H Goodman Christopher D CD Walters Maroya S MS Ragheb Daniel R T DRT Matthews Krista A KA Rajaram Krithika K Mishra Satish S McFadden Geoffrey I GI Sinnis Photini P Prigge Sean T ST
Proceedings of the National Academy of Sciences of the United States of America 20180226 11
Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that is the target of several classes of herbicides. Malaria parasites contain a plant-like ACC, and this is the only protein predicted to be biotinylated in the parasite. We found that ACC is expressed in the apicoplast organelle in liver- and blood-stage malaria parasites; however, it is activated through biotinylation only in the liver stages. Consistent with this observation, deletion of the biotin ligase responsible for ACC biotinyla ...[more]