Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen HA
PROVIDER: S-EPMC5856643 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nguyen Hien Anh HA Su Ying Y Zhang Jenny Y JY Antanasijevic Aleksandar A Caffrey Michael M Schalk Amanda M AM Liu Li L Rondelli Damiano D Oh Annie A Mahmud Dolores L DL Bosland Maarten C MC Kajdacsy-Balla Andre A Peirs Sofie S Lammens Tim T Mondelaers Veerle V De Moerloose Barbara B Goossens Steven S Schlicht Michael J MJ Kabirov Kasim K KK Lyubimov Alexander V AV Merrill Bradley J BJ Saunthararajah Yogen Y Van Vlierberghe Pieter P Lavie Arnon A
Cancer research 20180117 6
Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer, although about 4 of every 10 cases occur in adults. The enzyme drug l-asparaginase serves as a cornerstone of ALL therapy and exploits the asparagine dependency of ALL cells. In addition to hydrolyzing the amino acid l-asparagine, all FDA-approved l-asparaginases also have significant l-glutaminase coactivity. Since several reports suggest that l-glutamine depletion correlates with many of the side effects of these d ...[more]