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Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness.

ABSTRACT: Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.

SUBMITTER: Han L

PROVIDER: S-EPMC5857222 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness.

Han Liang L Limjunyawong Nathachit N Ru Fei F Li Zhe Z Hall Olivia J OJ Steele Haley H Zhu Yuyan Y Wilson Julie J Mitzner Wayne W Kollarik Marian M Undem Bradley J BJ Canning Brendan J BJ Dong Xinzhong X

Nature neuroscience 20180205 3

Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma. ...[more]

PMID: 29403029

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