Ontology highlight
ABSTRACT:
SUBMITTER: Lasho TL
PROVIDER: S-EPMC5858483 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Lasho Terra L TL Mudireddy Mythri M Finke Christy M CM Hanson Curtis A CA Ketterling Rhett P RP Szuber Natasha N Begna Kebede H KH Patnaik Mrinal M MM Gangat Naseema N Pardanani Animesh A Tefferi Ayalew A
Blood advances 20180201 4
Among 248 consecutive patients with blast phase myeloproliferative neoplasm (MPN-BP), DNA collected at the time of blast transformation was available in 75 patients (median age, 66 years; 64% men). MPN-BP followed primary myelofibrosis in 39 patients, essential thrombocythemia in 20 patients, and polycythemia vera in 16 patients. A myeloid neoplasm-relevant 33-gene panel was used for next-generation sequencing. Driver mutation distribution was <i>JAK2</i> 57%, <i>CALR</i> 20%, <i>MPL</i> 9%, and ...[more]