Ontology highlight
ABSTRACT:
SUBMITTER: Bremer HD
PROVIDER: S-EPMC5859008 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Bremer Hanna D HD Landegren Nils N Sjöberg Ronald R Hallgren Åsa Å Renneker Stefanie S Lattwein Erik E Leonard Dag D Eloranta Maija-Leena ML Rönnblom Lars L Nordmark Gunnel G Nilsson Peter P Andersson Göran G Lilliehöök Inger I Lindblad-Toh Kerstin K Kämpe Olle O Hansson-Hamlin Helene H
Scientific reports 20180319 1
Dogs can spontaneously develop complex systemic autoimmune disorders, with similarities to human autoimmune disease. Autoantibodies directed at self-antigens are a key feature of these autoimmune diseases. Here we report the identification of interleukin enhancer-binding factors 2 and 3 (ILF2 and ILF3) as autoantigens in canine immune-mediated rheumatic disease. The ILF2 autoantibodies were discovered in a small, selected canine cohort through the use of human protein arrays; a method not previo ...[more]