Ontology highlight
ABSTRACT:
SUBMITTER: Wu YW
PROVIDER: S-EPMC5859083 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Wu Yi-Wen YW Hsu Kai-Cheng KC Lee Hsueh-Yun HY Huang Tsui-Chin TC Lin Tony E TE Chen Yi-Ling YL Sung Ting-Yi TY Liou Jing-Ping JP Hwang-Verslues Wendy W WW Pan Shiow-Lin SL HuangFu Wei-Chun WC
Frontiers in pharmacology 20180313
The combination cancer therapy is a new strategy to circumvent drug resistance for the treatment of high metastasis and advanced malignancies. Herein, we developed a synthesized compound MPT0B451 that display inhibitory effect against histone deacetylase (HDAC) 6 and tubulin assembly. Our data demonstrated that MPT0B451 significantly inhibited cancer cell growths in HL-60 and PC-3 cells due to inhibition of HDAC activity. MPT0B451 also markedly increased caspase-mediated apoptosis in these cells ...[more]