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Alternative Splicing of FOXP3-Virtue and Vice.

ABSTRACT: FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOXP3 are discussed.

SUBMITTER: Mailer RKW

PROVIDER: S-EPMC5859138 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Alternative Splicing of FOXP3-Virtue and Vice.

Mailer Reiner K W RKW

Frontiers in immunology 20180313

FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOX ...[more]

PMID: 29593749

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