Ontology highlight
ABSTRACT:
SUBMITTER: Mailer RKW
PROVIDER: S-EPMC5859138 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in immunology 20180313
FOXP3 is the lineage-defining transcription factor of CD4+ CD25+ regulatory T cells. While many aspects of its regulation, interaction, and function are conserved among species, alternatively spliced FOXP3 isoforms are expressed only in human cells. This review summarizes current knowledge about alternative splicing of FOXP3 and the specific functions of FOXP3 isoforms in health and disease. Future perspectives in research and the therapeutic potential of manipulating alternative splicing of FOX ...[more]