Unknown

Dataset Information

0

FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing.


ABSTRACT: FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes. We report here that FOXP3 associates with heterogeneous nuclear ribonucleoprotein (hnRNP) F through the exon 2-encoded region of FOXP3 and the second quasi-RNA recognition motif (qRRM) of hnRNPF. FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing. Furthermore, overexpression of mouse hnRNPF in in vitro-differentiated regulatory T cells (Tregs) reduced their suppressive function. Thus, our studies identify a novel mechanism by which FOXP3 regulates mRNA alternative splicing to modulate the function of regulatory T cells.

SUBMITTER: Du J 

PROVIDER: S-EPMC6028976 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC2665901 | biostudies-literature
| S-EPMC10651857 | biostudies-literature
| S-EPMC4526142 | biostudies-literature
| S-EPMC3500379 | biostudies-literature
| S-EPMC2665233 | biostudies-literature
| S-EPMC11331657 | biostudies-literature
| S-EPMC7003074 | biostudies-literature
| S-EPMC6930371 | biostudies-literature
| S-EPMC3339278 | biostudies-literature
| S-EPMC4615681 | biostudies-literature