Ontology highlight
ABSTRACT:
SUBMITTER: Sharbeen G
PROVIDER: S-EPMC4428371 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Sharbeen George G McCarroll Joshua J Goldstein David D Phillips Phoebe A PA
Frontiers in nutrition 20150327
Pancreatic ductal adenocarcinoma (PDA) is a highly chemoresistant and metastatic disease with a dismal 5-year survival rate of 6%. More effective therapeutic targets and approaches are urgently needed to tackle this devastating disease. The base excision repair (BER) pathway has been identified as a predictor of therapeutic response, prognostic factor, and therapeutic target in a variety of cancers. This review will discuss our current understanding of BER in PDA and its potential to improve PDA ...[more]