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Daily Physical Activity Patterns During the Early Stage of Alzheimer's Disease.


ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disease that results in severe disability. Very few studies have explored changes in daily physical activity patterns during early stages of AD when components of physical function and mobility may be preserved.Our study explored differences in daily physical activity profiles, independent of the effects of non-cognitive factors including physical function and age, among individuals with mild AD compared to controls.Patients with mild AD and controls (n?=?92) recruited from the University of Kansas Alzheimer's Disease Center Registry, wore the Actigraph GT3X+ for seven days, and provided objective physical function (VO2 max) and mobility data. Using multivariate linear regression, we explored whether individuals with mild AD had different daily average and diurnal physical activity patterns compared to controls independent of non-cognitive factors that may affect physical activity, including physical function and mobility.We found that mild AD was associated with less moderate-intensity physical activity (p?

SUBMITTER: Varma VR 

PROVIDER: S-EPMC5859579 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Daily Physical Activity Patterns During the Early Stage of Alzheimer's Disease.

Varma Vijay R VR   Watts Amber A  

Journal of Alzheimer's disease : JAD 20170101 2


<h4>Background</h4>Alzheimer's disease (AD) is a neurodegenerative disease that results in severe disability. Very few studies have explored changes in daily physical activity patterns during early stages of AD when components of physical function and mobility may be preserved.<h4>Objective</h4>Our study explored differences in daily physical activity profiles, independent of the effects of non-cognitive factors including physical function and age, among individuals with mild AD compared to cont  ...[more]

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