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A mechanism for epigenetic control of DNA replication.

ABSTRACT: DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication. Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4. Abrogation of this interaction impairs TICRR binding to acetylated chromatin and disrupts normal S-phase progression. Our data reveal a novel function for BET proteins and establish the TICRR-BET interaction as a potential mechanism for epigenetic control of DNA replication.

SUBMITTER: Sansam CG

PROVIDER: S-EPMC5859964 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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A mechanism for epigenetic control of DNA replication.

Sansam Courtney G CG Pietrzak Katarzyna K Majchrzycka Blanka B Kerlin Maciej A MA Chen Jingrong J Rankin Susannah S Sansam Christopher L CL

Genes & development 20180226 3-4

DNA replication origins in hyperacetylated euchromatin fire preferentially during early S phase. However, how acetylation controls DNA replication timing is unknown. TICRR/TRESLIN is an essential protein required for the initiation of DNA replication. Here, we report that TICRR physically interacts with the acetyl-histone binding bromodomain (BRD) and extraterminal (BET) proteins BRD2 and BRD4. Abrogation of this interaction impairs TICRR binding to acetylated chromatin and disrupts normal S-pha ...[more]

PMID: 29483155

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