IL-6 and IL-10 are associated with good prognosis in early stage invasive breast cancer patients.
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ABSTRACT:
SUBMITTER: Ahmad N
PROVIDER: S-EPMC5860102 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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IL-6 and IL-10 are associated with good prognosis in early stage invasive breast cancer patients.
Ahmad Narmeen N Ammar Aula A Storr Sarah J SJ Green Andrew R AR Rakha Emad E Ellis Ian O IO Martin Stewart G SG
Cancer immunology, immunotherapy : CII 20171218 4
Macrophage-associated cytokines play an important role in cancer metastasis; however, the functions of interleukins (IL) 6 and 10 in breast cancer (BC) progression and metastasis are not clear. In this study the roles of IL-6/IL-10 in regulating vascular invasion and their prognostic significance in BC are investigated. MDA-MB-231 and MCF-7 migration (± IL-6 or IL-10) was assessed by scratch wound assay. Cancer cell adhesion to IL-6/IL-10 stimulated blood and lymphatic endothelial cells (EC) was ...[more]
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