Ontology highlight
ABSTRACT:
SUBMITTER: Yang R
PROVIDER: S-EPMC5860987 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Yang Rui R Yang Enzhuo E Shen Ling L Modlin Robert L RL Shen Hongbo H Chen Zheng W ZW
Journal of immunology (Baltimore, Md. : 1950) 20180216 7
The ability of <i>Mycobacterium tuberculosis</i> to block host antimicrobial responses in infected cells provides a key mechanism for disease pathogenesis. The immune system has evolved to overcome this blockade to restrict the infection, but it is not clear whether two key innate cytokines (IL-12/IL-18) involved in host defense can enhance antimycobacterial mechanisms. In this study, we demonstrated that the combination of IL-12 and IL-18 triggered an antimicrobial response against mycobacteria ...[more]