Ontology highlight
ABSTRACT:
SUBMITTER: Cruz A
PROVIDER: S-EPMC4588696 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Frontiers in immunology 20150930
The fate of infected macrophages is a critical aspect of immunity to mycobacteria. By depriving the pathogen of its intracellular niche, apoptotic death of the infected macrophage has been shown to be an important mechanism to control bacterial growth. Here, we show that IL-17 inhibits apoptosis of Mycobacterium bovis BCG- or Mycobacterium tuberculosis-infected macrophages thus hampering their ability to control bacterial growth. Mechanistically, we show that IL-17 inhibits p53, and impacts on t ...[more]