Ontology highlight
ABSTRACT:
SUBMITTER: Hassler MR
PROVIDER: S-EPMC5861422 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Nucleic acids research 20180301 5
Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable delivery to target tissues. Partially modified siRNAs (up to 70% of the nucleotides) provide significant stabilization in vitro and are commercially available; thus are commonly used to evaluate efficacy of bio-conjugates for in vivo delivery. In contrast, most clinically-advanced non-formulated compounds, using conjugation as a delivery strategy, are ...[more]