Ontology highlight
ABSTRACT:
SUBMITTER: Uehara K
PROVIDER: S-EPMC9122583 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Uehara Keiji K Harumoto Toshimasa T Makino Asana A Koda Yasuo Y Iwano Junko J Suzuki Yasuhiro Y Tanigawa Mari M Iwai Hiroto H Asano Kana K Kurihara Kana K Hamaguchi Akinori A Kodaira Hiroshi H Atsumi Toshiyuki T Yamada Yoji Y Tomizuka Kazuma K
Nucleic acids research 20220501 9
Extrahepatic delivery of small interfering RNAs (siRNAs) may have applications in the development of novel therapeutic approaches. However, reports on such approaches are limited, and the scarcity of reports concerning the systemically targeted delivery of siRNAs with effective gene silencing activity presents a challenge. We herein report for the first time the targeted delivery of CD206-targetable chemically modified mannose-siRNA (CMM-siRNA) conjugates to macrophages and dendritic cells (DCs) ...[more]