Ontology highlight
ABSTRACT:
SUBMITTER: Carballo GB
PROVIDER: S-EPMC5861627 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cell communication and signaling : CCS 20180320 1
Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of tumors. Most of the brain tumors are resistant to chemotherapeutic drugs, consequently, they have a poor prognosis. So, a better knowledge of the Shh pathway opens an opportunity for targeted therapies against brain tumors considering a multi-factori ...[more]