Ontology highlight
ABSTRACT:
SUBMITTER: Schaefer GI
PROVIDER: S-EPMC3703668 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Schaefer Giannina I GI Perez José R JR Duvall Jeremy R JR Stanton Benjamin Z BZ Shamji Alykhan F AF Schreiber Stuart L SL
Journal of the American Chemical Society 20130625 26
The Hedgehog signaling pathway is involved in the development of multicellular organisms and, when deregulated, can contribute to certain cancers, among other diseases. The molecular characterization of the pathway, which has been enabled by small-molecule probes targeting its components, remains incomplete. Here, we report the discovery of two potent, small-molecule inhibitors of the Sonic Hedgehog (Shh) pathway, BRD50837 and BRD9526. Both compounds exhibit stereochemistry-based structure-activ ...[more]