How to Synthesise High Purity, Crystalline d-Glucaric Acid Selectively.
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ABSTRACT:
SUBMITTER: Armstrong RD
PROVIDER: S-EPMC5861666 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
How to Synthesise High Purity, Crystalline d-Glucaric Acid Selectively.
Armstrong Robert D RD Kariuki Benson M BM Knight David W DW Hutchings Graham J GJ
European journal of organic chemistry 20171206 45
Glucaric acid has potential applications in food, pharmaceutical and polymer industries yet no methodology exists within the public domain for isolation of this key bio-derived platform molecule as a pure, crystalline solid. Here we demonstrate the difficulties, which arise in doing so and report development of a process for derivation of free-glucaric acid from its Ca<sup>2+</sup>/K<sup>+</sup> glucarate salts, which are both commercially available. Employing Amberlyst-15 (H<sup>+</sup>) exchan ...[more]
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