Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC5861726 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Wang Wenjing W Satyavolu Nitya Sai Reddy NSR Wu Zhenkun Z Zhang Jian-Rong JR Zhu Jun-Jie JJ Lu Yi Y
Angewandte Chemie (International ed. in English) 20170504 24
DNAzymes have enjoyed success as metal ion sensors outside cells. Their susceptibility to metal-dependent cleavage during delivery into cells has limited their intracellular applications. To overcome this limitation, a near-infrared (NIR) photothermal activation method is presented for controlling DNAzyme activity in living cells. The system consists of a three-stranded DNAzyme precursor (TSDP), the hybridization of which prevents the DNAzyme from being active. After conjugating the TSDP onto go ...[more]