Ontology highlight
ABSTRACT:
SUBMITTER: Singh J
PROVIDER: S-EPMC5861859 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Singh Jatinder J Minster Ryan L RL Schupf Nicole N Kraja Aldi A Liu YongMei Y Christensen Kaare K Newman Anne B AB Kammerer Candace M CM
The journals of gerontology. Series A, Biological sciences and medical sciences 20171001 10
<h4>Background</h4>Identification of genes or fundamental biological pathways that regulate aging phenotypes and longevity could lead to possible interventions to increase healthy longevity.<h4>Methods</h4>Using data from the Long Life Family Study, we performed genomewide association analyses on an endophenotype construct, LF1, comprising a linear combination of traits across health domains. LF1 primarily reflected traits from the pulmonary and physical activity domains.<h4>Results</h4>We detec ...[more]