Dataset Information

Genome-wide Association Study of Parental Life Span.

ABSTRACT: Having longer lived parents has been shown to be an important predictor of health trajectories and life span. As such, parental life span is an important phenotype that may uncover genes that affect longevity.A genome-wide association study of parental life span in participants of European and African ancestry from the Health and Retirement Study was conducted.A genome-wide significant association was observed for rs35715456 (log10BF = 6.3) on chromosome 18 for the dichotomous trait of having at least one long-lived parent versus not having any long-lived parent. This association was not replicated in an independent sample from the InCHIANTI and Framingham Heart Study. The most significant association among single nucleotide polymorphisms in longevity candidate genes (APOE, MINIPP1, FOXO3, EBF1, CAMKIV, and OTOL1) was observed in the EBF1 gene region (rs17056207, p = .0002).A promising genetic signal for parental life span was identified but was not replicated in independent samples.

SUBMITTER: Tanaka T

PROVIDER: S-EPMC5861941 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Genome-wide Association Study of Parental Life Span.

Tanaka Toshiko T Dutta Ambarish A Pilling Luke C LC Xue Luting L Lunetta Kathryn L KL Murabito Joanne M JM Bandinelli Stefania S Wallace Robert R Melzer David D Ferrucci Luigi L

The journals of gerontology. Series A, Biological sciences and medical sciences 20171001 10

<h4>Background</h4>Having longer lived parents has been shown to be an important predictor of health trajectories and life span. As such, parental life span is an important phenotype that may uncover genes that affect longevity.<h4>Methods</h4>A genome-wide association study of parental life span in participants of European and African ancestry from the Health and Retirement Study was conducted.<h4>Results</h4>A genome-wide significant association was observed for rs35715456 (log10BF = 6.3) on c ...[more]

PMID: 27816938

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Project description:BACKGROUND:Bovine respiratory disease complex (BRDC) is one of the most important sources of loss within the beef cattle industry in the USA. Steps have been taken to reduce the incidence of BRDC through vaccination. Despite the effectiveness of vaccines, large proportions of cattle still experience morbidity and mortality. Identification of genomic regions that are associated with variation in response to vaccination would allow for the selection of individuals genetically predisposed to respond to vaccination based on specific markers, while heritability and accuracy estimates would help facilitate genomic selection. This in turn may lead to selection for beef cattle herds that may have lower incidence rate of BRDC after vaccination. This study utilizes an Angus herd of more than 2000 head of cattle to identify these regions of association. RESULTS:Genome wide association studies were performed for viral neutralization antibody level and response to vaccination traits against four different viruses associated with BRDC: bovine viral diarrhea virus 1 and 2 (BVDV1 and BVDV2), bovine respiratory syncytial virus (BRSV), and bovine herpesvirus (BHV1). A total of six 1-Mb windows were associated with greater than 1% of the genetic variance for the analyzed vaccination response traits. Heritabilities ranged from 0.08 to 0.21 and prediction accuracy ranged from 0.01 to 0.33 across 7 different vaccination traits. CONCLUSIONS:Although six 1-Mb windows were identified as associated with 1% or greater genetic variance for viral neutralization antibody level and response to vaccination traits, few genes around these windows could readily be considered candidates. This indicates the need for further functional genomic annotation, as these regions appear to be gene deserts. Traits ranged from lowly to moderately heritable, which indicated the potential for selection of individuals that are genetically pre-disposed to respond to vaccination. The relatively low amount of genetic variance accounted for by any 1-Mb window indicated that viral neutralization antibody level and response to vaccination traits are polygenic in nature. Selection for these traits is possible, but likely to be slow due to the low heritabilities and absence of markers with high genetic variation associated with them.

Dataset Information

Genome-wide Association Study of Parental Life Span.

Publications

Genome-wide Association Study of Parental Life Span.

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