Ontology highlight
ABSTRACT:
SUBMITTER: Hinchcliff M
PROVIDER: S-EPMC7305248 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Hinchcliff Monique M O'Reilly Steven S O'Reilly Steven S
Current rheumatology reports 20200619 8
<h4>Purpose of review</h4>Systemic sclerosis (SSc) is an autoimmune connective tissue disease in which there is an activation of fibroblast to a myofibroblast that secretes huge amounts of extracellular matrix. Currently, no treatment exists that modifies the fibrosis elements and new therapeutic targets are badly needed. This review examines the current state of treatments and emerging therapeutics.<h4>Recent findings</h4>Nintedanib was found to significantly reduce the rate of decline in SSc a ...[more]