Ontology highlight
ABSTRACT:
SUBMITTER: Pinto-Diez C
PROVIDER: S-EPMC5862594 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Pinto-Díez Celia C García-Recio Eva M EM Pérez-Morgado M Isabel MI García-Hernández Marta M Sanz-Criado Lara L Sacristán Silvia S Toledo-Lobo M Val MV Pérez-Mies Belén B Esteban-Rodríguez Isabel I Pascual Alejandro A Garcia-Villanueva Mercedes M Martínez-Jañez Noelia N González Víctor M VM Martín M Elena ME
Oncotarget 20180205 17
MAP kinase interacting kinases (MNKs) modulate the function of oncogene eukaryotic initiation factor 4E (eIF4E) through phosphorylation, which is necessary for oncogenic transformation. MNK1 gives rise to two mRNAs and thus two MNK1 isoforms, named MNK1a and MNK1b. MNK1b, the splice variant of human MNK1a, is constitutively active and independent of upstream MAP kinases. In this study, we have analyzed the expression of both MNK1 isoforms in 69 breast tumor samples and its association with clini ...[more]