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Definitive chemoradiotherapy with low-dose continuous 5-fluorouracil reduces hematological toxicity without compromising survival in esophageal squamous cell carcinoma patients.


ABSTRACT: To compare chemoradiotherapy (CRT) with low-dose continuous 5-fluorouracil (5FU) to CRT with 5FU+cisplatin (CDDP) for esophageal squamous cell carcinoma (ESCC) in a retrospective cohort study.We reviewed the cases of Stage I-IV ESCC patients who underwent definitive CRT in 2000-2014. Concomitant chemotherapy was one of the three regimens: (1) high-dose intermittent 5FU and CDDP (standard-dose FP: SDFP), (2) low-dose continuous 5FU and CDDP (LDFP), or (3) low-dose continuous 5FU (LD5FU). The general selection criteria for chemotherapy were: SDFP for patients aged <70 yrs; LDFP for those aged 70-74 yrs; LD5FU for those aged ?75 yrs or with performance status (PS) ?3. Propensity scores were derived with chemotherapy (LD5FU vs. 5FU+CDDP) as the dependent variable.In a multivariate analysis, chemotherapy (LD5FU vs. SDFP, p?=?.24; LDFP vs. SDFP, p?=?.52) did not affect the overall survival (OS). LD5FU caused significantly less grade 3-4 leukopenia (9%) compared to SDFP (47%) and LDFP (44%) (p?

SUBMITTER: Saito H 

PROVIDER: S-EPMC5862669 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Definitive chemoradiotherapy with low-dose continuous 5-fluorouracil reduces hematological toxicity without compromising survival in esophageal squamous cell carcinoma patients.

Saito Hirotake H   Ohta Atsushi A   Abe Eisuke E   Kaidu Motoki M   Shioi Miki M   Nakano Toshimichi T   Oshikane Tomoya T   Tanaka Kensuke K   Maruyama Katsuya K   Kushima Naotaka N   Tanabe Satoshi S   Utsunomiya Satoru S   Sasamoto Ryuta R   Aoyama Hidefumi H  

Clinical and translational radiation oncology 20171224


<h4>Background and purpose</h4>To compare chemoradiotherapy (CRT) with low-dose continuous 5-fluorouracil (5FU) to CRT with 5FU+cisplatin (CDDP) for esophageal squamous cell carcinoma (ESCC) in a retrospective cohort study.<h4>Methods and materials</h4>We reviewed the cases of Stage I-IV ESCC patients who underwent definitive CRT in 2000-2014. Concomitant chemotherapy was one of the three regimens: (1) high-dose intermittent 5FU and CDDP (standard-dose FP: SDFP), (2) low-dose continuous 5FU and  ...[more]

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