Imaging of Claudin-4 in Pancreatic Ductal Adenocarcinoma Using a Radiolabelled Anti-Claudin-4 Monoclonal Antibody.

ABSTRACT:

Purpose

Despite its widespread use, the positron emission tomography (PET) radiotracer 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) has been shown in clinical settings to be ineffective for improving early diagnosis of pancreatic ductal adenocarcinoma (PDAC). A promising biomarker for PDAC detection is the tight junction protein claudin-4. The purpose of this study was to evaluate a new single-photon emission computed tomography (SPECT) imaging agent, [¹¹¹In]anti-claudin-4 mAb, with regard to its ability to allow visualisation of claudin-4 in a xenograft and a genetically engineered mouse model of PDAC.

Procedures

The ability of [¹¹¹In]anti-claudin-4 mAb to selectively target claudin-4 was assessed using two human xenograft tumour mo

SUBMITTER: Torres JB 

PROVIDER: S-EPMC5862916 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature