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Gray blood late gadolinium enhancement cardiovascular magnetic resonance for improved detection of myocardial scar.


ABSTRACT: BACKGROUND:Low scar-to-blood contrast in late gadolinium enhanced (LGE) MRI limits the visualization of scars adjacent to the blood pool. Nulling the blood signal improves scar detection but results in lack of contrast between myocardium and blood, which makes clinical evaluation of LGE images more difficult. METHODS:GB-LGE contrast is achieved through partial suppression of the blood signal using T2 magnetization preparation between the inversion pulse and acquisition. The timing parameters of GB-LGE sequence are determined by optimizing a cost-function representing the desired tissue contrast. The proposed 3D GB-LGE sequence was evaluated using phantoms, human subjects (n?=?45) and a swine model of myocardial infarction (n?=?5). Two independent readers subjectively evaluated the image quality and ability to identify and localize scarring in GB-LGE compared to black-blood LGE (BB-LGE) (i.e., with complete blood nulling) and conventional (bright-blood) LGE. RESULTS:GB-LGE contrast was successfully generated in phantoms and all in-vivo scans. The scar-to-blood contrast was improved in GB-LGE compared to conventional LGE in humans (1.1?±?0.5 vs. 0.6?±?0.4, P?

SUBMITTER: Fahmy AS 

PROVIDER: S-EPMC5863465 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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