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Prognostic and functional implications of left atrial late gadolinium enhancement cardiovascular magnetic resonance.


ABSTRACT:

Background

Left atrial (LA) late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging is indicative of fibrosis, and has been correlated with reduced LA function, increased LA volume, and poor procedural outcomes in cohorts with atrial fibrillation (AF). However, the role of LGE as a prognostic biomarker for arrhythmia in cardiac disease has not been examined.

Methods

In this study, we assessed LA LGE using a 3D LGE CMR sequence to examine its relationships with new onset atrial arrhythmia, and LA and left ventricular (LV) mechanical function.

Results

LA LGE images were acquired in 111 patients undergoing CMR imaging, including 66 patients with no prior history of an atrial arrhythmia. During the median follow-up of 2.7?years (interquartile range (IQR) 1.8-3.7?years), 15/66 (23%) of patients developed a new atrial arrhythmia. LA LGE ?10% of LA myocardial volume was significantly associated with an increased rate of new-onset atrial arrhythmia, with a hazard ratio of 3.16 (95% CI 1.14-8.72), p =?0.026. There were significant relationships between LA LGE and both LA ejection fraction (r =?-?0.39, p ConclusionsElevated LA LGE is associated with reduced LA function and reduced LV diastolic function. LA LGE is associated with new onset atrial arrhythmia during follow-up.

SUBMITTER: Quail M 

PROVIDER: S-EPMC6317232 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Prognostic and functional implications of left atrial late gadolinium enhancement cardiovascular magnetic resonance.

Quail Michael M   Grunseich Karl K   Baldassarre Lauren A LA   Mojibian Hamid H   Marieb Mark A MA   Cornfeld Daniel D   Soufer Aaron A   Sinusas Albert J AJ   Peters Dana C DC  

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20190103 1


<h4>Background</h4>Left atrial (LA) late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging is indicative of fibrosis, and has been correlated with reduced LA function, increased LA volume, and poor procedural outcomes in cohorts with atrial fibrillation (AF). However, the role of LGE as a prognostic biomarker for arrhythmia in cardiac disease has not been examined.<h4>Methods</h4>In this study, we assessed LA LGE using a 3D LGE CMR sequence to examine its relationsh  ...[more]

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