Ontology highlight
ABSTRACT:
SUBMITTER: Adhikarla H
PROVIDER: S-EPMC5863495 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Adhikarla Haritha H Wunder Elsio A EA Mechaly Ariel E AE Mehta Sameet S Wang Zheng Z Santos Luciane L Bisht Vimla V Diggle Peter P Murray Gerald G Adler Ben B Lopez Francesc F Townsend Jeffrey P JP Groisman Eduardo E Picardeau Mathieu M Buschiazzo Alejandro A Ko Albert I AI
Frontiers in cellular and infection microbiology 20180223
Leptospirosis is an emerging zoonotic disease with more than 1 million cases annually. Currently there is lack of evidence for signaling pathways involved during the infection process of <i>Leptospira</i>. In our comprehensive genomic analysis of 20 <i>Leptospira</i> spp. we identified seven pathogen-specific Two-Component System (TCS) proteins. Disruption of two these TCS genes in pathogenic <i>Leptospira</i> strain resulted in loss-of-virulence in a hamster model of leptospirosis. Correspondin ...[more]