Ontology highlight
ABSTRACT:
SUBMITTER: Antila CJM
PROVIDER: S-EPMC5864205 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Cell death and differentiation 20180105 3
The Notch signaling pathway is a key regulator of stem cells during development, and its deregulated activity is linked to developmental defects and cancer. Transcriptional activation of Notch target genes requires cleavage of the Notch receptor in response to ligand binding, production of the Notch intracellular domain (NICD1), NICD1 migration into the nucleus, and assembly of a transcriptional complex. Post-translational modifications of Notch regulate its trafficking, turnover, and transcript ...[more]