Ontology highlight
ABSTRACT:
SUBMITTER: Azar C
PROVIDER: S-EPMC5865118 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Azar Christopher C Valentine Mark M Trausch-Azar Julie J Druley Todd T Nelson D Michael DM Schwartz Alan L AL
Scientific reports 20180323 1
The fusion of villous cytotrophoblasts into the multinucleated syncytiotrophoblast is critical for the essential functions of the mammalian placenta. Using RNA-Seq gene expression and quantitative protein expression, we identified genes and their cognate proteins which are coordinately up- or down-regulated in two cellular models of cytotrophoblast to syncytiotrophoblast development, human primary villous and human BeWo cytotrophoblasts. These include hCGβ, TREML2, PAM, CRIP2, INHA, FLRG, SERPIN ...[more]