Ontology highlight
ABSTRACT:
SUBMITTER: Tomczak A
PROVIDER: S-EPMC5865181 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Tomczak Aurelie A Mortensen Jonathan M JM Winnenburg Rainer R Liu Charles C Alessi Dominique T DT Swamy Varsha V Vallania Francesco F Lofgren Shane S Haynes Winston W Shah Nigam H NH Musen Mark A MA Khatri Purvesh P
Scientific reports 20180323 1
Gene Ontology (GO) enrichment analysis is ubiquitously used for interpreting high throughput molecular data and generating hypotheses about underlying biological phenomena of experiments. However, the two building blocks of this analysis - the ontology and the annotations - evolve rapidly. We used gene signatures derived from 104 disease analyses to systematically evaluate how enrichment analysis results were affected by evolution of the GO over a decade. We found low consistency between enrichm ...[more]