Ontology highlight
ABSTRACT:
SUBMITTER: Kaushik S
PROVIDER: S-EPMC5865447 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Kaushik S S Liu F F Veazey K J KJ Gao G G Das P P Neves L F LF Lin K K Zhong Y Y Lu Y Y Giuliani V V Bedford M T MT Nimer S D SD Santos M A MA
Leukemia 20170630 2
The hematological malignancies classified as mixed lineage leukemias (MLL) harbor fusions of the MLL1 gene to partners that are members of transcriptional elongation complexes. MLL-rearranged leukemias are associated with extremely poor prognosis, and response to conventional therapies and efforts to identify molecular targets are urgently needed. Using mouse models of MLL-rearranged acute myeloid leukemia, here we show that genetic inactivation or small-molecule inhibition of the protein argini ...[more]