Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC5866196 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Chen Zhen Z Lichtor Phillip A PA Berliner Adrian P AP Chen Jonathan C JC Liu David R DR
Nature chemistry 20180305 4
The evolution of sequence-defined synthetic polymers made of building blocks beyond those compatible with polymerase enzymes or the ribosome has the potential to generate new classes of receptors, catalysts and materials. Here we describe a ligase-mediated DNA-templated polymerization and in vitro selection system to evolve highly functionalized nucleic acid polymers (HFNAPs) made from 32 building blocks that contain eight chemically diverse side chains on a DNA backbone. Through iterated cycles ...[more]