Ontology highlight
ABSTRACT:
SUBMITTER: Kong D
PROVIDER: S-EPMC5330676 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Kong Dehui D Lei Yi Y Yeung Wayland W Hili Ryan R
Angewandte Chemie (International ed. in English) 20161001 42
The development and in-depth analysis of T4 DNA ligase-catalyzed DNA templated oligonucleotide polymerization toward the generation of diversely functionalized nucleic acid polymers is described. The NNNNT codon set enables low codon bias, high fidelity, and high efficiency for the polymerization of ANNNN libraries comprising various functional groups. The robustness of the method was highlighted in the copolymerization of a 256-membered ANNNN library comprising 16 sub-libraries modified with di ...[more]