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Time to Peak Weight Loss During Extended Behavioral Treatment.

ABSTRACT: OBJECTIVE:This study was designed to examine the variability in timing of peak weight loss in behavioral treatment (BT), that is, when treatment participants reach their greatest amount of cumulative weight loss. METHODS:Secondary data analyses were conducted, drawing upon data from two clinical trials that provided 12 months of group-based BT, with sessions meeting less frequently in the second half of the treatment year. Weight was measured at the beginning of each treatment session. RESULTS:Cumulative proportions of participants reaching peak weight loss were as follows: 25.0% of study 1 and 20.0% of study 2 participants by month 4; 43.2% of study 1 and 52.2% of study 2 participants by month 6; 54.5% of study 1 and 77.8% of study 2 participants by month 8. Among participants who peaked after 4 months, the mean amount of additional weight loss achieved between 4 months and the peak session was 4.74 kg in study 1 and 4.07 kg in study 2. CONCLUSIONS:Substantial variability in the timing of peak weight loss was observed, with larger than expected proportions of participants reaching their greatest amount of cumulative weight loss in the final months of treatment. This variability may create methodological and clinical challenges.

SUBMITTER: Butryn ML

PROVIDER: S-EPMC5866205 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Time to Peak Weight Loss During Extended Behavioral Treatment.

Butryn Meghan L ML Call Christine C CC Schumacher Leah M LM Kerrigan Stephanie G SG Forman Evan M EM

Obesity (Silver Spring, Md.) 20180214 4

<h4>Objective</h4>This study was designed to examine the variability in timing of peak weight loss in behavioral treatment (BT), that is, when treatment participants reach their greatest amount of cumulative weight loss.<h4>Methods</h4>Secondary data analyses were conducted, drawing upon data from two clinical trials that provided 12 months of group-based BT, with sessions meeting less frequently in the second half of the treatment year. Weight was measured at the beginning of each treatment ses ...[more]

PMID: 29442440

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Project description:BACKGROUND:Antipsychotic-treated youth have increased risk for the development of obesity and type 2 diabetes. Behavioral weight loss treatments show promise in reducing obesity and diabetes risk in antipsychotic treated adults, but have received no study in antipsychotic treated youth. OBJECTIVE:We describe a rationale for behavioral weight loss interventions in high-weight antipsychotic treated youth, and report behavioral, anthropomorphic, and metabolic findings from a case series of obese antipsychotic-treated adolescents participating in a short-term, family-based behavioral weight loss intervention. METHODS:We adapted the Traffic Light Plan, a 16-week family-based weight loss intervention that promotes healthy energy balance using the colors of the traffic light to categorize the nutritional value of foods and intensity of physical activity, adapting a social ecological framework to address health behavior change in multiple social contexts. The intervention was administered to three obese adolescents with long-term antipsychotic medication exposure. Efficacy of the intervention was evaluated with a battery of anthropomorphic and metabolic assessments including weight, body mass index percentile, whole body adiposity, liver fat content, and fasting plasma glucose and lipids. Participants and their parents also filled out a treatment satisfaction questionnaire upon study completion. RESULTS:Two males and 1 female (all aged 14 years) participated. All 3 participants attended all 16 sessions, and experienced beneficial changes in adiposity, fasting lipids and liver fat content associated with weight stabilization or weight loss. Adolescents and their parents all reported a high level of satisfaction with the treatment. CONCLUSIONS:Family-based behavioral weight loss treatment can be feasibly delivered and is acceptable to antipsychotic-treated youth and their families. Randomized controlled trials are needed to fully evaluate the effectiveness and acceptability of behavioral weight loss interventions in antipsychotic treated youth and their families.

Dataset Information

Time to Peak Weight Loss During Extended Behavioral Treatment.

Publications

Time to Peak Weight Loss During Extended Behavioral Treatment.

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