Ontology highlight
ABSTRACT:
SUBMITTER: Francis JW
PROVIDER: S-EPMC5866932 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Francis Joel W JW Royer Christopher J CJ Cook Paul D PD
Protein science : a publication of the Protein Society 20180223 4
Bacillithiol is a low-molecular weight thiol produced by many gram-positive organisms, including Staphylococcus aureus and Bacillus anthracis. It is the major thiol responsible for maintaining redox homeostasis and cellular detoxification, including inactivation of the antibiotic fosfomycin. The metal-dependent bacillithiol transferase BstA is likely involved in these sorts of detoxification processes, but the exact substrates and enzyme mechanism have not been identified. Here we report the 1.3 ...[more]