Structural insights into the EthR-DNA interaction using native mass spectrometry.
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ABSTRACT:
SUBMITTER: Shiu-Hin Chan D
PROVIDER: S-EPMC5868724 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
Structural insights into the EthR-DNA interaction using native mass spectrometry.
Shiu-Hin Chan Daniel D Seetoh Wei-Guang WG McConnell Brendan N BN Matak-Vinković Dijana D Thomas Sherine E SE Mendes Vitor V Blaszczyk Michal M Coyne Anthony G AG Blundell Tom L TL Abell Chris C
Chemical communications (Cambridge, England) 20170301 25
EthR is a transcriptional repressor that increases Mycobacterium tuberculosis resistance to ethionamide. In this study, the EthR-DNA interaction has been investigated by native electrospray-ionization mass spectrometry for the first time. The results show that up to six subunits of EthR are able to bind to its operator. ...[more]
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