Ontology highlight
ABSTRACT:
SUBMITTER: Missinato MA
PROVIDER: S-EPMC5868992 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20180306 5
Zebrafish regenerate cardiac tissue through proliferation of pre-existing cardiomyocytes and neovascularization. Secreted growth factors such as FGFs, IGF, PDGFs and Neuregulin play essential roles in stimulating cardiomyocyte proliferation. These factors activate the Ras/MAPK pathway, which is tightly controlled by the feedback attenuator Dual specificity phosphatase 6 (Dusp6), an ERK phosphatase. Here, we show that suppressing Dusp6 function enhances cardiac regeneration. Inactivation of Dusp6 ...[more]