Ras/MAPK signaling from endomembranes.
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ABSTRACT: Signal transduction along the Ras/MAPK pathway has been generally thought to take place at the plasma membrane. It is now evident that the plasma membrane is not the only platform capable of Ras/MAPK signal induction. Fusion of Ras with green fluorescent protein and the development of genetically encoded fluorescent probes for Ras activation have revealed signaling events on a variety of intracellular membranes including endosomes, the Golgi apparatus and the endoplasmic reticulum. Thus, the Ras/MAPK pathway is spatially compartmentalized within cells and this may afford greater complexity of signal output.
SUBMITTER: Fehrenbacher N
PROVIDER: S-EPMC3003591 | biostudies-other | 2009 Aug
REPOSITORIES: biostudies-other
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