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Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action.

ABSTRACT: The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells.

SUBMITTER: Steele AD

PROVIDER: S-EPMC5869691 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action.

Steele Andrew D AD Steele Andrew D AD Ernouf Guillaume G Lee Young Eun YE Wuest William M WM

Organic letters 20180201 4

The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells. ...[more]

PMID: 29388431

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