Ontology highlight
ABSTRACT:
SUBMITTER: Lin LY
PROVIDER: S-EPMC5869878 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Lin Li-Ying LY Evans S E SE Fairall L L Schwabe John W R JWR Wagner Simon D SD Muskett Frederick W FW
Biomolecular NMR assignments 20170919 1
BCL6 is a transcriptional repressor. Two domains of the protein, the N-terminal BTB-POZ domain and the RD2 domain are responsible for recruitment of co-repressor molecules and histone deacetylases. The BTB-POZ domain is found in a large and diverse range of proteins that play important roles in development, homeostasis and neoplasia. Crystal structures of several BTB-POZ domains, including BCL6 have been determined. The BTB-POZ domain of BCL6 not only mediates dimerisation but is also responsibl ...[more]