Ontology highlight
ABSTRACT:
SUBMITTER: Caputo L
PROVIDER: S-EPMC5870759 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Caputo Luca L Witzel Hagen R HR Kolovos Petros P Cheedipudi Sirisha S Looso Mario M Mylona Athina A van IJcken Wilfred F J WF Laugwitz Karl-Ludwig KL Evans Sylvia M SM Braun Thomas T Soler Eric E Grosveld Frank F Dobreva Gergana G
Cell stem cell 20150827 3
Cardiac stem/progenitor cells hold great potential for regenerative therapies; however, the mechanisms regulating their expansion and differentiation remain insufficiently defined. Here we show that Ldb1 is a central regulator of genome organization in cardiac progenitor cells, which is crucial for cardiac lineage differentiation and heart development. We demonstrate that Ldb1 binds to the key regulator of cardiac progenitors, Isl1, and protects it from degradation. Furthermore, the Isl1/Ldb1 co ...[more]