Ontology highlight
ABSTRACT:
SUBMITTER: Lebeau J
PROVIDER: S-EPMC5870888 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Lebeau Justine J Saunders Jaclyn M JM Moraes Vivian W R VWR Madhavan Aparajita A Madrazo Nicole N Anthony Mary C MC Wiseman R Luke RL
Cell reports 20180301 11
Endoplasmic reticulum (ER) stress is transmitted to mitochondria and is associated with pathologic mitochondrial dysfunction in diverse diseases. The PERK arm of the unfolded protein response (UPR) protects mitochondria during ER stress through the transcriptional and translational remodeling of mitochondrial molecular quality control pathways. Here, we show that ER stress also induces dynamic remodeling of mitochondrial morphology by promoting protective stress-induced mitochondrial hyperfusion ...[more]