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Mitochondrial retrograde signaling to the endoplasmic-reticulum regulates unfolded protein responses.

ABSTRACT: Unfolded protein response (UPRs) directs adaption or apoptosis depending on the severity of endoplasmic-reticulum (ER) stress. We found that apoptotic signaling by inositol requiring enzyme 1? (IRE1?), a transducer of UPRs, is suppressed by mitochondrial ubiquitin ligase MITOL/MARCH5 on ER-mitochondria contacts, suggesting that mitochondria regulate cell fate under ER stress.

SUBMITTER: Takeda K

PROVIDER: S-EPMC6816402 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Mitochondrial retrograde signaling to the endoplasmic-reticulum regulates unfolded protein responses.

Takeda Keisuke K Yanagi Shigeru S

Molecular & cellular oncology 20190911 6

Unfolded protein response (UPRs) directs adaption or apoptosis depending on the severity of endoplasmic-reticulum (ER) stress. We found that apoptotic signaling by inositol requiring enzyme 1α (IRE1α), a transducer of UPRs, is suppressed by mitochondrial ubiquitin ligase MITOL/MARCH5 on ER-mitochondria contacts, suggesting that mitochondria regulate cell fate under ER stress. ...[more]

PMID: 31692879

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