Unknown

Dataset Information

0

Mitochondrial retrograde signaling to the endoplasmic-reticulum regulates unfolded protein responses.


ABSTRACT: Unfolded protein response (UPRs) directs adaption or apoptosis depending on the severity of endoplasmic-reticulum (ER) stress. We found that apoptotic signaling by inositol requiring enzyme 1? (IRE1?), a transducer of UPRs, is suppressed by mitochondrial ubiquitin ligase MITOL/MARCH5 on ER-mitochondria contacts, suggesting that mitochondria regulate cell fate under ER stress.

SUBMITTER: Takeda K 

PROVIDER: S-EPMC6816402 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

altmetric image

Publications

Mitochondrial retrograde signaling to the endoplasmic-reticulum regulates unfolded protein responses.

Takeda Keisuke K   Yanagi Shigeru S  

Molecular & cellular oncology 20190911 6


Unfolded protein response (UPRs) directs adaption or apoptosis depending on the severity of endoplasmic-reticulum (ER) stress. We found that apoptotic signaling by inositol requiring enzyme 1α (IRE1α), a transducer of UPRs, is suppressed by mitochondrial ubiquitin ligase MITOL/MARCH5 on ER-mitochondria contacts, suggesting that mitochondria regulate cell fate under ER stress. ...[more]

Similar Datasets

| S-EPMC5870888 | biostudies-literature
| S-EPMC524730 | biostudies-literature
2011-02-17 | E-GEOD-27349 | biostudies-arrayexpress
| S-EPMC6156401 | biostudies-literature
| S-EPMC7897600 | biostudies-literature
| S-EPMC3578356 | biostudies-literature
2011-02-17 | GSE27349 | GEO
| S-EPMC9125394 | biostudies-literature
| S-EPMC8127406 | biostudies-literature
| S-EPMC4640732 | biostudies-literature