Ontology highlight
ABSTRACT:
SUBMITTER: Hoseth EZ
PROVIDER: S-EPMC5871764 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Hoseth Eva Z EZ Krull Florian F Dieset Ingrid I Mørch Ragni H RH Hope Sigrun S Gardsjord Erlend S ES Steen Nils Eiel NE Melle Ingrid I Brattbakk Hans-Richard HR Steen Vidar M VM Aukrust Pål P Djurovic Srdjan S Andreassen Ole A OA Ueland Thor T
Scientific reports 20180328 1
The Notch signaling pathway plays a crucial role in neurodevelopment and in adult brain homeostasis. We aimed to further investigate Notch pathway activity in bipolar disorder (BD) and schizophrenia (SCZ) by conducting a pathway analysis. We measured plasma levels of Notch ligands (DLL1 and DLK1) using enzyme immunoassays in a large sample of patients (SCZ n = 551, BD n = 246) and healthy controls (HC n = 639). We also determined Notch pathway related gene expression levels by microarray analyse ...[more]