Ontology highlight
ABSTRACT:
SUBMITTER: Navarro G
PROVIDER: S-EPMC5871782 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Navarro Gemma G Cordomí Arnau A Casadó-Anguera Verónica V Moreno Estefanía E Cai Ning-Sheng NS Cortés Antoni A Canela Enric I EI Dessauer Carmen W CW Casadó Vicent V Pardo Leonardo L Lluís Carme C Ferré Sergi S
Nature communications 20180328 1
G protein-coupled receptors (GPCRs), G proteins and adenylyl cyclase (AC) comprise one of the most studied transmembrane cell signaling pathways. However, it is unknown whether the ligand-dependent interactions between these signaling molecules are based on random collisions or the rearrangement of pre-coupled elements in a macromolecular complex. Furthermore, it remains controversial whether a GPCR homodimer coupled to a single heterotrimeric G protein constitutes a common functional unit. Usin ...[more]